Accuracy Redefined with NOVA Markers
See More. Treat Better. Trust NOVA.
Why Choose NOVA?
NOVA establishes a new benchmark in Cancer Care – providing MRI clarity and precise targeting that enables physicians to plan and deliver treatment with confidence.
Clear Imaging without Compromise
The only positive-signal MRI marker engineered for exceptional clarity on MRI, CT, and other imaging modalities.
Optimized for Every Workflow
Choose NOVA MR for MRI-based planning or NOVA Z for CT workflows.
Proven Results backed by Clinical Evidence
Where innovation meets clinical proof.
NOVA establishes a new benchmark in Cancer Care – providing MRI clarity and precise targeting that enables physicians to plan and deliver treatment with confidence.
- Positive-signal MRI visibility
- Great for MR-based planning
- Removes the issue of metallic artifacts
Built for all imaging modalities, NOVA Z delivers exceptional visibility with minimal artifact and reduced dose perturbation. It’s an ideal choice for clinics where MRI-positive imaging isn’t essential – offering exceptional performance.
- Minimal artifact
- Ideal for Radiotherapy
- Extended shelf life
Which One Fits Your Workflow Best?
NOVA MR and NOVA Z are precision-engineered fiducial markers designed to support accurate targeting.
| NOVA MR | NOVA Z | |
|---|---|---|
|
Visibility |
Positive MRI signal, artifact-free |
CT-focused, minimal artifact |
|
Material & Design |
Non-metallic composite marker |
Ceramic-based |
|
Artifacts / Dose Perturbation |
Very low |
Very low |
|
Workflow Advantages |
Ideal when MRI clarity is critical |
Optimized for non-MRI workflows |
|
Needle Gauge & Implant Comfort |
Standard 18-gauge |
Standard 18-gauge |
In Summary
Choose Nova MR when MRI-based imaging is central to your workflow. NOVA Z when your primary focus is on CT-based treatment planning and workflow.
From the Founder
Steven J. Frank, MD is the Founder of C4 Imaging and a Professor of Radiation Oncology at MD Anderson Cancer Center. He started C4 Imaging in 2010 with a heartfelt vision: to give patients and physicians greater confidence in Cancer Treatment by making imaging clearer and more reliable. Inspired by his daily work caring for patients, Dr. Frank pioneered the world’s first positive-signal MRI marker, SIRIUS, which opened the door to new possibilities in precision care. This breakthrough became the foundation for C4 Imaging’s growing family of products, including ORION for HDR brachytherapy and NOVA for External Beam Radiation therapy. What began as a single innovation is now a shared mission – to reduce uncertainty, improve outcomes, and bring clarity and peace of mind to every patient’s journey through Cancer Care.
Clinician Endorsements
Trusted Insights from Leaders on the Frontline of Cancer Care.
Dr. Andrew Farach
Houston Methodist Hospital
“NOVA provides crisp, reliable visibility across ultrasound, CT, and MRI-offering the only MRI-positive, non-metallic fiducial marker available. This clarity has significantly enhanced our MRI fusion workflows for Brachytherapy, SBRT, and EBRT, enabling more confident targeting and safer, more precise care.”
Dr. Peter Rossi
Callaway-Young Cancer Center Valley View
“In my practice, NOVA is revolutionizing precision medicine. It boasts the lowest dose perturbation, eliminates CT streak and MRI susceptibility artifacts, and offers fast and efficient MRI-CT fusion treatment planning. With NOVA, I can deliver targeted therapy like never before.”
Dr. Shalin Shah
UT MD Anderson
“NOVA really accelerates our ability to attain zero harm. That’s our holy grail – is to treat our patients to the best of our abilities, cure their cancer, but then achieve zero harm. I think NOVA helps us get to that goal.”
Your Next Step
Starts Here
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Clinical & Reimbursement
Support for Physicians
Access reimbursement guides, coverage and clinical resources for C4 Imaging’s Markers.